Allergies - Pain without Gain Allergies are a common problem that affects 20% of Americans, and the prevalence of allergy has lately been on the rise. Allergies are caused by a glitch in the immune system. In any normal immune system, plasma cells produce proteins called antibodies, which patrol the body like tiny police officers in search of proteins that are foreign to the body and signal the presence of a problematic invader. When antibodies find such an invader, they alert the immune cell authorities to trigger an immune response. The least common kind of antibody, immunoglobulin E (IgE), is normally present in very low amounts and is only used to set off an immune reaction in response to a parasitic infection.
However, some people have hereditary predispositions to react to harmless compounds (allergens) such as food proteins, animal hair proteins, plant pollens, drugs, or substances like latex. IgE antibodies bind to immune cells called mast cells and basophils, which are concentrated in skin and mucous membrane surfaces. When the body is exposed to the allergen recognized by IgE, the antibody tells the cells to "degranulate", releasing all kinds of signaling mediators including histamine. These mediators immediately act on surrounding tissues to make blood vessels dilate and smooth muscle contract. Depending on where the allergen is found, this reaction will produce symptoms ranging from irritated sinuses to itchy skin to breathing difficulties.
Allergies can be combated by blocking the allergic response or by targeting inappropriate inflammation, which lies at the root of allergic symptoms. AllerQue contains several natural compounds that work together to relieve the misery of allergies.
Rosemary Rosemary contains a compound called rosmarinic acid which has been shown to be highly beneficial for the relief of allergy symptoms. A randomized, double-blind, age-matched placebo-controlled parallel group study observed the effects of rosmarinic acid on 30 patients with seasonal allergic rhinoconjunctivitis (SAR). At the end of the trial period, there was a significant relief of itchy nose, watery eyes, itchy eyes and total symptoms. 55.6-70% of patients given rosmarinic acid reported global symptom relief, compared to only 30% of the placebo group.
Rosmarinic acid is well absorbed from the gastrointestinal tract and besides its effects on allergies; it is a powerful antioxidant with a range of health benefits. Rosemary has also been shown to help relieve headaches.
Quercetin Quercetin is the most widely consumed flavonoid in the diet and has been used to treat a variety of complaints. Cellular and animal studies have found it to be a potent inhibitor of allergic and inflammatory responses. Quercetin acts to inhibit histamine release and is widely used by those who suffer from constant allergies (such as dust) and seasonal allergies (such as hay fever). It is also a powerful antioxidant, and has benefits in heart health and diabetic complications. High intakes of quercetin are linked to lower mortality rates and heart attack
Butterbur Butterbur (petasites hybridus) is a shrub found in Europe and in parts of Asia and North America. A study of patients with asthma or bronchitis found that butterbur improved lung ventilation and bronchial reactivity. Another study found that petasites had a comparable effect to the antihistamine Cetirizine for seasonal allergic rhinitis, likely due to its effectiveness at reducing nasal responsiveness. It did not have the sedative effect associated with the drug.
Migraines are another disorder characterized by inappropriate inflammation, and in a double-blind placebo-controlled study, butterbur supplementation led to up to a 60% decrease in migraine frequency compared to the placebo group, and the migraine symptoms decreased in duration and intensity.
The ingredients in AllerQue work at a number of levels to block allergic responses and alleviate the associated symptoms. Quercetin blocks the production of IgE, thereby inhibiting the allergic response from developing in the first place. Several of the compounds are able to stabilize mast cells to prevent them from degranulating and releasing histamine and other pro-inflammatory mediators. Rosemary inhibits a key step of the complement system, which is an alternate pathway of inflammation.
Some of the cytokines that are primarily responsible for allergic diseases include interleukin (IL)-4 and IL-5. IL-4 is one of the most important cytokines in the production of IgE and allergic inflammation. IL-5 is responsible for recruiting eosinophils, which are immune cells that assist in priming the immune system for an allergic response and are responsible for releasing pro-inflammatory mediators. Eosinophil accumulation is a distinctive feature of allergic inflammation. Rosemary and quercetin is able to block the production of IL-4 and IL-5, and the subsequent recruitment and activation of eosinophils.
For those who are sick of dealing with itching, sneezing, watery eyes, difficulty breathing, or even worse symptoms, the compounds of AllerQue are brought together to provide a natural solution for allergies.