About Genestra Brands Bio B12+ Folic Acid 60t
High-dose B12 formula with folic acid
- Helps to prevent vitamin B12 deficiency
- Helps to form red blood cells
- Helps the body to metabolize carbohydrates, fats, and proteins
- Helps reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy
- Provides 1000 mcg of vitamin B12 and 400 mcg of folic acid per dose
Bio B12 + Folic Acid includes a high-dose of vitamin B12 to help support macronutrient metabolism and prevent vitamin B12 deficiency.1 Vitamin B12 is an important cofactor for two enzymatic reactions: 1) methylmalonyl-CoA mutase, which helps break down branch chain amino acids and odd numbered fatty acids; 2) methionine synthase, which is needed for methyl transfer reactions, including the folic acid dependent conversion of homocysteine to methionine for protein production.2 Daily supplementation with 400 mcg of folic acid during the first trimester helps decrease neural tube defects by approximately 50%.3 As folic acid is a methyl group donor, research indicates that neural tube defects may result from impaired methylation.4 Similarly, decreases in the availability of vitamin B12 or folic acid lead to the accumulation of homocysteine, which may inhibit methyl transfer reactions.4 Vitamin B12 helps enhance methionine synthesis and increases the ability of folic acid to lower homocysteine levels for normal methyl metabolism.5,6 The vitamin is also required for the methylation of proteins involved in the synthesis and maintenance of myelin, and vitamin deficiencies can result in decreased production of myelin sheath, material needed for normal nervous system function.7,8 As methionine synthase is needed to form red blood cells, deficiencies in vitamin B12 have been associated with the production of abnormally large and irregularly shaped blood cells.7
References
1. Allen, LH. Am J Clin Nutr. 2009; 89(suppl): 693S-696S.
2. Nielsen, MJ, Rasmussen, MR, Andersen, CBF, Nexo, E, Moestrup, SK. Nat. Rev. Gastroenterol. Hepatol. 2012; 9: 345-354.
3. Osterhues, A, Ali, NS, Michels, KB. Critical Reviews in Food Science and Nutrition. 2013; 53: 1180-1190.
4. Imbard, A, Benoist, JF, Blom, HJ. Int. J. Environ. Res. Public Health. 2013; 10: 4352-4389.
5. Fenech, M. Mutation Research. 2012; 733: 21- 33.
6. Czeizel, AE, Dudàs, I, Vereczkey, A, Bànhidy, F. Nutrients. 2013; 5: 4760-4775.
7. Briani, C, Dalla Torre, C, Citton, V, Manara, R, Pompanin, S, Binotto, G, Adami, F. Nutrients. 2013; 5: 4521-4539.
8. Rush, EC, Katre, P, CS Yajnik, CS. European Journal of Clinical Nutrition. 2014; 68: 2-7.
High-dose B12 formula with folic acid
- Helps to prevent vitamin B12 deficiency
- Helps to form red blood cells
- Helps the body to metabolize carbohydrates, fats, and proteins
- Helps reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy
- Provides 1000 mcg of vitamin B12 and 400 mcg of folic acid per dose
Bio B12 + Folic Acid includes a high-dose of vitamin B12 to help support macronutrient metabolism and prevent vitamin B12 deficiency.1 Vitamin B12 is an important cofactor for two enzymatic reactions: 1) methylmalonyl-CoA mutase, which helps break down branch chain amino acids and odd numbered fatty acids; 2) methionine synthase, which is needed for methyl transfer reactions, including the folic acid dependent conversion of homocysteine to methionine for protein production.2 Daily supplementation with 400 mcg of folic acid during the first trimester helps decrease neural tube defects by approximately 50%.3 As folic acid is a methyl group donor, research indicates that neural tube defects may result from impaired methylation.4 Similarly, decreases in the availability of vitamin B12 or folic acid lead to the accumulation of homocysteine, which may inhibit methyl transfer reactions.4 Vitamin B12 helps enhance methionine synthesis and increases the ability of folic acid to lower homocysteine levels for normal methyl metabolism.5,6 The vitamin is also required for the methylation of proteins involved in the synthesis and maintenance of myelin, and vitamin deficiencies can result in decreased production of myelin sheath, material needed for normal nervous system function.7,8 As methionine synthase is needed to form red blood cells, deficiencies in vitamin B12 have been associated with the production of abnormally large and irregularly shaped blood cells.7
References
1. Allen, LH. Am J Clin Nutr. 2009; 89(suppl): 693S-696S.
2. Nielsen, MJ, Rasmussen, MR, Andersen, CBF, Nexo, E, Moestrup, SK. Nat. Rev. Gastroenterol. Hepatol. 2012; 9: 345-354.
3. Osterhues, A, Ali, NS, Michels, KB. Critical Reviews in Food Science and Nutrition. 2013; 53: 1180-1190.
4. Imbard, A, Benoist, JF, Blom, HJ. Int. J. Environ. Res. Public Health. 2013; 10: 4352-4389.
5. Fenech, M. Mutation Research. 2012; 733: 21- 33.
6. Czeizel, AE, Dudàs, I, Vereczkey, A, Bànhidy, F. Nutrients. 2013; 5: 4760-4775.
7. Briani, C, Dalla Torre, C, Citton, V, Manara, R, Pompanin, S, Binotto, G, Adami, F. Nutrients. 2013; 5: 4521-4539.
8. Rush, EC, Katre, P, CS Yajnik, CS. European Journal of Clinical Nutrition. 2014; 68: 2-7.
EACH TABLET CONTAINS: Vitamin B12 (hydroxocobalamin) . . . . . . . . . . . . .1000 mcg Folate (folic acid) . . . . .400 mcg
Non-Medicinal Ingredients: Mannitol, maltodextrin, cellulose, ascorbyl palmitate, natural cherry flavour, silica
Recommended Dose: Adults, Adolescents and Children (4 years and older): Chew 1 tablet daily or as recommended by your healthcare practitioner.
Genestra Brands Bio B12+ Folic Acid 60t Disclaimer
Nature's Source is committed to ensuring the complete and absolute accuracy of product images and information on our website. However, please be aware that there may be pending updates to packaging or ingredients due to manufacturing changes.
Occasionally, some items may be shipped with alternate packaging that has been recently updated by the supplier or manufacturer. It's important to note that while packaging may change, the ingredients usually remain the same. We always advise you to read labels, warnings, and product directions before use. Please do not solely rely on the information provided by Healthy Planet Canada.
Probiotics Disclaimer:
Our probiotics are stored in our warehouse under refrigeration to guarantee quality and maintain optimal potency. Additionally, we include a FREE ice pack with probiotic shipments. Although the product may not arrive cold, the ice pack helps in preserving a cooler temperature during transit. We recommend taking into account potential weekend or holiday delays when placing your order. For example, it's best to order on a weekday and avoid ordering on Fridays, Saturdays, or during holidays
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