S-Adenosylmethionine (SAM(e)) is an important physiological agent formed in the body by combining the essential amino acid methionine with adenosine-triphosphate (ATP). SAM(e) is involved in over 40 biochemical reactions in the body. It functions closely with folic acid and vitamin B12 in â€œmethylationâ€ reactionsâ€”the process of adding a single carbon unit (a methyl group) to another molecule. Methylation reactions are critical in the manufacture of many body componentsâ€”especially brain chemicalâ€”and in detoxification reactions. SAM(e) is also required in the manufacture of all sulfur-containing compounds in the human body, including glutathione and various sulfur-containing cartilage components. The beneficial effects of SAM(e) supplementation are far-reaching because of its central role in so many metabolic processes.