S-Adenosylmethionine (SAM(e)) is an important physiological agent formed in the body by combining the essential amino acid methionine with adenosine-triphosphate (ATP). SAM(e) is involved in over 40 biochemical reactions in the body. It functions closely with folic acid and vitamin B12 in “methylation” reactions—the process of adding a single carbon unit (a methyl group) to another molecule. Methylation reactions are critical in the manufacture of many body components—especially brain chemical—and in detoxification reactions. SAM(e) is also required in the manufacture of all sulfur-containing compounds in the human body, including glutathione and various sulfur-containing cartilage components. The beneficial effects of SAM(e) supplementation are far-reaching because of its central role in so many metabolic processes.