Adrenal Response is a complete adaptogenic formula for adrenal health.s A full range of supportive adaptogens is included to achieve the maximum biological activity: Rhodiola extract Rhodiola rosea — A well-documented adaptogenic herb included in the formula for its action primarily upon the hypothalamus in the brain, which functions to normalize the manner in which the body responds to stress triggers and to maintain equilibrium within the HPA. Rhodiola has also been shown to enhance the transport of tryptophan and 5-HTP (serotonin precursors), as well as to help to support mood.s American ginseng root Panax quinquefolius — Pharmacologically, ginseng is nonspecific in its effects and is capable of a normalizing action irrespective of the pathological situation; it has been successfully used to normalize the body's stress response. American ginseng is also considered to have a calming effect on an overstimulated nervous system. It may also help to strengthen the adrenal glands themselves in individuals suffering from chronic stress. Astragalus root Astragalus membranaceus — An important adaptogenic herb which, in studies, has indicated to stimulate pituitary-adrenal cortical activity. Astragalus is also an effective remedy for immuno-compromised individuals, a common condition associated with adrenal dysfunction.s Holy basil Ocimum sanctum — An adaptogenic herb, one of the primary botanicals used in Ayurvedic medicine to modulate a physiological stress response and to increase adaptive energy. Traditional Ayurvedic use for anti-stress activity has been verified by numerous animal clinical studies. A variety of studies have also shown holy basil to support the health of the cardiovascular, immune and digestive systems. Schizandra berry Schisandra chinensis — Included for its renowned ability to help restore integrity to the adrenal glands, and to promote a greater sense of energy and stamina. The adaptogenic properties of this herb help to improve the body's response to stress, as well as support immune function.s As a vegetarian formula, Adrenal Response is one of the most studied and validated adrenal supplements available. For adaptogens with additional nutrient support, we also offer Adrenal Response Complete Care.